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Roessler, C., Tting, C., Meleshin, M., Steegborn, C

4.3 Pharmacokinetic parameters in Sprague-Dawley rats after intravenous and intramuscular administration A total of 324 SD rats were randomly divided into five groups, including 66 rats in group one, 60 rats each in groups two to four, and 78 rats in group five, with each group comprising half male and half female subjects

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Through several mechanisms, including direct interaction with SUR1 and membrane depolarization, intracellular calcium mobilization, and insulin granule priming modification, EPAC2 activation may promote the exocytosis of insulin granules [55, 56]